Mathematical modeling and computational prediction of cancer drug resistance
نویسندگان
چکیده
منابع مشابه
Mathematical Modeling and Lyapunov-Based Drug Administration in Cancer Chemotherapy
In this paper a new mathematical model is developed for the dynamics between tumor cells, normal cells, immune cells, chemotherapy drug concentration and drug toxicity. Then, the theorem of Lyapunov stability is applied to design treatment strategies for drug protocols that ensure a desired rate of tumor cell kill and push the system to the area with smaller tumor cells. Using of this theorem a...
متن کاملMathematical Oncology Prediction of Drug Response in Breast Cancer Using Integrative Experimental/Computational Modeling
Nearly 30% of women with early-stage breast cancer develop recurrent disease attributed to resistance to systemic therapy. Prevailing models of chemotherapy failure describe three resistant phenotypes: cells with alterations in transmembrane drug transport, increased detoxification and repair pathways, and alterations leading to failure of apoptosis. Proliferative activity correlates with tumor...
متن کاملMathematical Modeling of Therapy-induced Cancer Drug Resistance: Connecting Cancer Mechanisms to Population Survival Rates
Drug resistance significantly limits the long-term effectiveness of targeted therapeutics for cancer patients. Recent experimental studies have demonstrated that cancer cell heterogeneity and microenvironment adaptations to targeted therapy play important roles in promoting the rapid acquisition of drug resistance and in increasing cancer metastasis. The systematic development of effective ther...
متن کاملMathematical Modeling / Computational Mathematics
My research is focused on mathematical modeling in the interdisciplinary areas of materials science and crystal growth and on development of advanced computational methods for tracking material/fluid surfaces and interfaces. Primarily, I am interested in modeling formation of a micro(nano)structure arrays as a result of the morphological (shape) instabilities of a solid film surfaces, material ...
متن کاملHybrid Modeling of Cancer Drug Resistance Mechanisms
Cancer is a multi-scale disease and its overwhelming complexity depends upon the multiple interwind events occurring at both molecular and cellular levels, making it very difficult for therapeutic advancements in cancer research. The resistance to cancer drugs is a significant challenge faced by scientists nowadays. The roots of the problem reside not only at the molecular level due to multiple...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Briefings in Bioinformatics
سال: 2017
ISSN: 1467-5463,1477-4054
DOI: 10.1093/bib/bbx065